Development of affinity polymeric particles for the removal of 4-dimethylaminopyridine (DMAP) from active pharmaceutical ingredient crude streams using a green technology

نویسندگان

چکیده

Polymeric particles with affinity for 4-dimethylaminipyridine (DMAP) were developed by molecular imprinting using supercritical carbon dioxide (scCO2) technology, cleanup of this potentially genotoxic impurity from crude mixtures Active Pharmaceutical Ingredients (APIs). DMAP-molecularly imprinted polymer (DMAP-MIP) and the respective control, non-molecularly (NIP) produced free radical polymerization methacrylic acid as monomer, ethylene glycol dimethacrylate crosslinker AIBN free-radical initiator in scCO2. The materials obtained high yield characterized chemically, physically morphologically. Their extraction efficiency was evaluated dynamic binding experiments two solutions: i) a solution containing 104 ppm DMAP solution; ii) model pharmaceutical mixture 1018 Mometasone furoate (API). Particles able to remove 18.3 µmol DMAP/g (i) 1004.6 API (ii). In addition, recoveries both obtained, above 99%.

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ژورنال

عنوان ژورنال: Journal of Supercritical Fluids

سال: 2023

ISSN: ['1872-8162', '0896-8446']

DOI: https://doi.org/10.1016/j.supflu.2023.105853